The utility of lidocaine in neonatal conviction syndrome

Authors

DOI:

https://doi.org/10.59471/ijhsc2024178

Keywords:

lidocaine, anticonvulsants, lidocaine utility, seizure symdrome, neonatal

Abstract

BACKGROUND: Lidocaine is a drug belonging to the local anesthetics; it is rapidly distributed in the body and metabolized in the liver. At commonly recommended doses, the therapeutic index of lidocaine remains very high and plasma concentrations remain largely below neurotoxic, cardiotoxic and other thresholds. It is used during various medical procedures, and in the nervous system it acts by binding to a specific site which is the sodium channel receptor of the neural membrane and blocking the passage of ions. The present study is of interest to know the potential usefulness of lidocaine in neonates with convulsive syndrome. In order to implement improvements in the treatment of those who need it. In this way, pediatric neurologists can achieve better results in the interventions to treat this pathology. Methods: In the present systematic review we try to answer and perform a literature search through pubmed and others to analyze the usefulness of lidocaine in neonatal convulsive syndrome and its potential benefit. Results: After the application of the inclusion and exclusion criteria, we will be able to identify the groups of newborns most at risk and the efficacy of lidocaine treatment. Conclusion: It is concluded that lidocaine is the third drug used in neonatal convulsive syndrome for maintenance where it is received as a continuous infusion and is effective in suppressing electroclinical seizures; excessive doses should be avoided as it can also produce convulsions and other adverse effects in children.

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References

Gerardo Ochoa-Anaya, Claudia

Patricia Aguirre-Ibarra, Montserrat Franco-Cabrera. Lidocaína: aspectos generales y nuevas implicaciones en la inflamación. 2017;(3).

Castelló JC, Gómez LA, Villar GV, Serrano MM. Convulsiones neonatales. Protocolo de manejo.

Lidocaína | Asociación Española de Pediatría [Internet]. [citado 3 de agosto de 2023]. Disponible en: https://www.aeped.es/comitemedicamentos/pediamecum/lidocaina

Glass HC, Pham TN, Danielsen B, Towner D, Glidden D, Wu YW.

Antenatal and Intrapartum Risk

Factors for Seizures in Term

Newborns: A Population-Based Study,

California 1998-2002. The Journal of Pediatrics. 1 de enero de 2009;154(1):24-28.e1.

Alonso García B, Samper Villagrasa MP. Crisis convulsivas en el neonato. Zaragoza: Universidad de Zaragoza; 2019.

REVISION BIBLIOGRÁFICA

CONVULCIONES NEONATALES.pdf

[Internet]. [citado 3 de agosto de 2023]. Disponible en: https://www.kerwa.ucr.ac.cr/bitstream/ handle/10669/79937/REVISION%20BI BLIOGR%c3%81FICA%20CONVULCI ONES%20%20NEONATALES.pdf?se quence=1&isAllowed=y

Troncoso A L, Menéndez G P, Hernández Ch M. Convulsiones neonatales: diagnóstico y manejo.

Revista chilena de pediatría. mayo de 2001;72(3):190-8.

Feld DV. CONVULSIONES NEONATALES. Normas de

evaluación, diagnóstico y tratamiento.

a9_1_tr_convulsionesneonatales.pdf [Internet]. [citado 2 de agosto de 2023]. Disponible en:

https://www.revistachilenadeepilepsia. cl/revistas/revista_2008/a9_1_tr_conv ulsionesneonatales.pdf

a9_1_tr_convulsionesneonatales.pdf [Internet]. [citado 3 de agosto de 2023]. Disponible en: https://www.revistachilenadeepilepsia. cl/revistas/revista_2008/a9_1_tr_conv ulsionesneonatales.pdf

Evans D, Levene M. Neonatal seizures. Arch Dis Child Fetal Neonatal Ed. enero de 1998;78(1):F70-5.

Barba DJP. EVALUACIÓN Y MANEJO DEL NIÑO CON LESION NEUROLÓGICA GRAVE.

Published

2024-03-05

How to Cite

1.
Marie Milange J, Estrin MA. The utility of lidocaine in neonatal conviction syndrome. Interamerican Journal of Health Sciences [Internet]. 2024 Mar. 5 [cited 2024 Jul. 21];4:178. Available from: https://ijhsc.com/journal/article/view/178

Issue

Section

Review Article