Interamerican Journal of Health Sciences <p><strong>Interamerican Journal of Health Sciences</strong><span data-preserver-spaces="true"> is the peer-reviewed scientific journal edited by the <strong>School of Medicine and Health Sciences </strong>of the <strong><a href="" target="_blank" rel="noopener">Universidad Abierta Interamericana</a></strong>. The main objective of <strong>IJHS </strong>is to provide Health Professionals with comprehensive valued information and high-quality research related to biomedical sciences, clinical practice, and medical education. <strong>IJHS </strong>is published in different volumes a year, and the online edition is open access.</span></p> <p><strong><span data-preserver-spaces="true">IJHS</span></strong><span data-preserver-spaces="true">'s mission is to produce, propagate, and preserve biomedical knowledge by the highest standards to improve patients outcomes and enhance medical education.</span></p> <p><em>This journal prints original and unpublished contributions that meet the journal's current editorial standards.</em></p> <p>The collaboration of the editors, authors and reviewers of this journal and the ethics guide for editorial processes is governed by the Principles of transparency and good practice in academic publications of the <a href="">Committee on Publication Ethics (COPE),</a> <a href="">EQUATOR Network (Enhancing the QUAlity and Transparency Of health Research), </a><a href="">World Association of Medical Editors </a>, <a href="">Open Access Scholarly Publishers Association</a> , <a href="">ICMJE (International Committee of Medical Journal Editors)</a> and <a href="">DOAJ (Directory of Open Access Journals)</a></p> Universidad Abierta Interamericana en-US Interamerican Journal of Health Sciences 2953-3724 Cardiovascular risk associated with the use of selective COX-2 inhibitors: a systematic review <p>Introduction: Selective inhibitors of the enzyme cyclooxygenase-2 were developed to reduce the gastrointestinal toxicity of conventional nonsteroidal anti-inflammatory drugs. However, this class of drugs decreases prostacyclin production and can disrupt endothelial homeostatic balance, leading to a prothrombotic state that offsets potential gastrointestinal benefits.<br>Methods: A systematic review of all study publications linking cyclooxygenase-2 inhibitor nonsteroidal anti-inflammatory drugs and related cardiovascular events was performed.<br>Results: The highest overall risks were seen with rofecoxib, 1.45 (95% CI 1.33 to 1.59), and diclofenac, 1.40 (1.27 to 1.55). The lowest risks recorded were with ibuprofen, 1.18 (1.11, 1.25), and naproxen, 1.09 (1.02, 1.16). The risk of VTE increased with diclofenac [OR 1.63 (95% CI: 1.53, 1.74)], ibuprofen [OR = 1.49 (95% CI: 1.38, 1.62)], meloxicam [OR = 1.29 (95% CI: 1.11, 1.50)] and coxibs [celecoxib, OR= 1.30 (95% CI: 1.11, 1.51); rofecoxib, OR= 1.44 (95% CI: 1.18, 1.76)]. Naproxen did not increase the risk of VTE [OR = 1.00 (95% CI: 0.89, 1.12)]. Furthermore, there is a significant association with atrial fibrillation for etoricoxib (HR 1.35; 95% CI 1.19–1.54). <br>Conclusion: This review suggests that the risk of these adverse effects is greater in patients with an earlier history of cardiovascular disease or at considerable risk for developing it. Evidence shows that among the widely used NSAIDs, low-dose naproxen and ibuprofen are less likely to increase cardiovascular risk. Data for etoricoxib were sparse, but in pairwise comparisons this drug had a significantly higher relative risk than either naproxen or ibuprofen. Indomethacin is an older drug that is also toxic to the gastrointestinal system, and evidence of cardiovascular risk casts doubt on its continued clinical use.</p> Raissa Costa Leite Lucio Silva Marcelo Adrian Estrin Copyright (c) 2022 Raissa Costa Leite Lucio Silva, Marcelo Adrian Estrin 2022-12-01 2022-12-01 2 118 118 Relevance of the learning provided by the field of research for academic training in surgical instrumentation <p>With great enthusiasm, I see that in your magazine Interamerican Journal of Health Sciences, relevance is given to the learning that the field of scientific research provides to the surgical instrumentation training. Science as human activity, creator of knowledge through observation methodologies and experimentation in order to answer questions objectively and systematically, manifests benefits at a global level with the generation of knowledge, the application of these in the development of innovative technologies and in the decision-making with the purpose of solving individual and collective human problems, among others. Scientific practice requires trained personnel to access reference sources and tools that allow critical, consensual and objective reflection in the execution of all stages in the development of an investigation. This is nothing more than a personnel that has learned to learn by itself to obtain evidence that will be useful, reliable and timely to resolve the research questions. There is where remains the main individual benefit of science.</p> Vanesa Verónica Miana Copyright (c) 2022 Vanesa Verónica Miana 2022-11-02 2022-11-02 2 111 111 Continuing Medical Professional Development, a look beyond the individual <p>In a context where the medical community envisions the importance of maintaining the necessary skills for professional performance, I consider it truly valuable for the Interamerican Journal of Health Sciences to be part of this debate, broadening the possible perspectives on this problem. In a changing world, where knowledge is permanently challenged, where we constantly interact with technology and where the needs of the community require an increasingly complex approach, it is worth questioning whether what we have learned in our undergraduate and postgraduate instances is enough in order to continue performing our tasks in an ideal manner. The capabilities defined in training programs seem not to be sufficient indefinitely as to guarantee an adequate and responsible response to the population.</p> Jorge Nicolás Ninno Copyright (c) 2022 Jorge Nicolás Ninno 2022-12-03 2022-12-03 2 121 121 Pneumonitis secondary to silicone lung embolism in transgender women living with HIV <p>Dimethylpolysiloxane (silicone) has been widely used in the last decades in soft tissue augmentation procedures. In Argentina, approximately 54% of transgender people had liquid silicone or industrial oil injection and 91% of them where applied outside the health system. Silicone particles may migrate into lung vessels generating a syndrome similar to fat embolism, usually starting within 72 hours following silicone injection, although it has been described months to years after. We hereby present two cases of pneumonitis secondary to silicone lung embolism in transgender women living with HIV. Both patients were diagnosed through CT scan and bronchoalveolar lavage, and received supportive therapy with favorable outcome. Silicone lung embolism should be included as a differential diagnosis of pneumonitis, especially in transgender population.</p> Julian Garcia Andres Benchetrit Ignacio Martin Yamila Masuero Marcela Natiello Nuria Lázari Diana Troncoso Ruben Solari Roberto Dure Liliana Castro Zorrilla Copyright (c) 2022 Julian Garcia, Andres Benchetrit, Ignacio Martin, Yamila Masuero, Marcela Natiello, Nuria Lázari, Diana Troncoso, Ruben Solari, Roberto Dure, Liliana Castro Zorrilla 2022-11-02 2022-11-02 2 112 112 Hepatitis B reactivation after COVID-19: just a coincidence or a causal relationship? <p>A 48 year-old man was evaluated because of a sudden raise in his liver function tests. He had a prior history of an acute hepatitis B infection, which spontaneously resolved in 2015 and a recent COVID-19 infection. As he only developed a mild disease, he did not receive steroids or convalescent plasma, or any other drugs. Seven weeks after having acquired the infection, he presented an acute hepatitis. Every known etiological factor was discarded. New serological status for hepatitis B was evaluated, and we discovered a sero-reversion. This situation could often be seen after immunosuppressive treatments, but our patient receive none of them. We started Entecavir and a rapid negativization of his viral load was observed as well as a normalization of his liver tests. If this reactivation was a consequence of COVID-19 or not is still not clear for us, but we believe that this case could raise awareness among physicians.</p> Fernando Gruz Paola Rama Diego Halac Copyright (c) 2022 Fernando Gruz, Paola Rama, Diego Halac 2022-12-02 2022-12-02 2 119 119 Disturbances of lung function in HIV positive patients <p>The presence of disturbances in the respiratory function on HIV positive patients, derive from multiple causes. The principal mechanism of injury is the inflammation that triggers a flood of biomarkers, which leads to a respiratory function decline. Within the causes, we find modifiable factors such as tobacco and drugs use, and non-modifiable factors like gender, age, CD4 recount, viral burden, HIV itself, ART, co-infections such us HCV and the presence of breathing infections like Pneumocystis Jiroveci pneumonia and Tuberculosis. Facing a chronic pathology requires to control obstructive alterations so, it results convenient to request spirometry and diffusion tests.</p> Agostini Marcela Copyright (c) 2022 Agostini Marcela 2022-12-02 2022-12-02 2 120 120